Special synthetic request
Customized synthesis, separation and purification of high optical purity of chiral compounds and standards based on Medinoah’s powerful chemical synthesis capabilities and proven analytical platform
-- High efficiency, high optical purity and chiral preparative chromatography
Preparation of chiral compounds by chemical methods or column chromatography
-- Chiral synthesis
Synthesis of chiral molecules is based on the structure of target molecules
Medinoah’s ADC technology platform provides a reasonable design and synthesis scheme for coupling of small molecule compounds (including small molecule drugs, toxins and active compounds) and antibodies. The product is available in 1 mg to 10 g.
Synthesis of conjugates with cysteine, lysine, and enzyme
Apply Design of Experiments (DOE) to quickly and efficiently screen all relevant reaction parameters for optimization of drug loading and drug-antibody ratio
Chromatographic purification methods such as SEC, HIC, IEX, UF/DF, etc.
Characterization methods such as UV, SEC, HIC, RP, LC-MS, SEC-MALL, endotoxin analysis, etc.
Multi-mode coupling technology to meet ADC drug development needs
Based on Medinoah’s synthetic advantages of small molecule drugs and linkers, we can meet the diversified needs of customers
Drug impurities (related substances)
Enrichment, separation, purification, structural identification, structural confirmation and analytical characterization of drug impurities
Synthesis of target impurities
Synthesis and modification of literature reported compounds
Currently, we have more than 100 catalog compound libraries of off-patent drug impurities, with continuous effort to expand according to the development of off-patent drugs, in stock and/or customized synthesis.